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Endocrine System

The I and II ...

Question

The ___ I_ and II_ polypeptides of human insulin are linked together by _III___ bonds.

A

I - A chain, II - B chain, III - ionic bond

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B

I - A chain, II - B chain, III - disulphide bridges

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C

I - B chain, II - C chain, III - hydrogen bonds

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D

I - A chain, II - C chain, III - disulphide bonds

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Solution

The correct option is B I - A chain, II - B chain, III - disulphide bridges
Human insulin is a peptide hormone which helps regulate blood sugar level. In mammals, insulin is synthesised as a prohormone which needs to be processed before it becomes a fully mature and functional hormone. This proinsulin contains 3 peptide chains- A, B and C. This C peptide is not present in the mature insulin and is removed during maturation into insulin. Mature human insulin is made up of two polypeptide chains, A and B. The two polypeptide chains are interconnected by disulphide bridges or -S-S- linkages.

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Endocrine System

Standard X Biology

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