Question

What are systematic and non systematic antacids with explination

5 marks

Answer 1

For 5 marks question you must start with basic intro of acidity, how antacid work, constituents of antacid, definition with examples of systemic antacids and non-systemic antacid.
Ans -
Gastric acidity occurs due to excessive secretion of HCl in stomach due to various reasons. Antacids are the substances which reduce gastric acidity resulting in an increase in the pH of stomach and duodenum.
Antacids are alkaline bases used to neutralize the excess gastric HCl.
Systemic antacids:
Systemic antacids are antacids which get systemically absorbed e.g. sodium carbonate is water soluble and potent neutralizer, but it is not suitable for the treatment of peptic ulcer because of risk of ulcer perforation due to production of carbon dioxide in the stomach.
Non Systemic antacids:
They are insoluble and poorly absorbed systemically. In Magnesium salt, Magnesium carbonate is most water soluble and reacts with HCl at a slow rate, while Magnesium hydroxide has low solubility and has the power to absorb and inactivate pepsin and to protect the ulcer base.