1. Endoplasmic reticulum is a continuous membrane, which is present in both plant cells, animal cells and absent in prokaryotic cells.
2. It is the membrane of network tubules and flattened sacs, which serves a variety of functions within the cell.
3. The space, which is present in the endoplasmic reticulum, is called as the lumen.
Rough Endoplasmic reticulum
Rough ER is named for its rough appearance, which is due to the ribosomes attached to its outer (cytoplasmic) surface.
Rough ER lies immediately adjacent to the cell nucleus, and its membrane is continuous with the outer membrane of the nuclear envelope.
Smooth Endoplasmic reticulum
Smooth Endoplasmic reticulum, by contrast, is not associated with ribosomes, and its functions differ.
The smooth ER is involved in the synthesis of lipids, including cholesterol and phospholipids, which are used in the production of new cellular membrane.