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What is the function of histones in DNA packaging?
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Solution
Histones:
Histones are positively charged proteins rich in basic amino acids such as lysine and arginine.
Role of histones in DNA packaging :
- 8 histone protein units form histone octamer.
- DNA is negatively charged and wraps around positively charged histone octamer to stabilise the charge.
- Approximately, 200bp of DNA wrap around one histone octamer.
- Linker DNA is a double-stranded DNA of 38-53 bp long in between two nucleosome cores.
- Linker DNA in association with histone H1, holds the cores together.
- DNA wrapper around the histone octamer forms a nucleosome.
- Nucleosomes on DNA form a ‘beads on string’ appearance, where the nucleosome forms the beads and the linker DNA is seen as the string.
- This nucleosome further condenses to attain a higher order structure called chromatin.
Histones are positively charged proteins rich in basic amino acids such as lysine and arginine.
Role of histones in DNA packaging :
- 8 histone protein units form histone octamer.
- DNA is negatively charged and wraps around positively charged histone octamer to stabilise the charge.
- Approximately, 200bp of DNA wrap around one histone octamer.
- Linker DNA is a double-stranded DNA of 38-53 bp long in between two nucleosome cores.
- Linker DNA in association with histone H1, holds the cores together.
- DNA wrapper around the histone octamer forms a nucleosome.
- Nucleosomes on DNA form a ‘beads on string’ appearance, where the nucleosome forms the beads and the linker DNA is seen as the string.
- This nucleosome further condenses to attain a higher order structure called chromatin.
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