Question

Write equations of Friedel-Crafts reaction alkylation of anisole, nitration of anisole, bromination of anisole in ethanoic acid medium, and Friedel-Crafts acetylation of anisole.

Answer 1

Friedel-Crafts reaction :

• In order to attach substituents to an aromatic ring, Charles Friedel and James Crafts created a series of reactions in 1877 known as the Friedel-Crafts reactions.
• Alkylation reactions and acylation reactions are the two primary categories of Friedel-Crafts processes.
• Both of these reactions work by substituting electrophilic aromatics.

Anisole :

• Methoxybenzene, often known as anisole, is a chemical substance having the formula ${\mathrm{C}}_7{\mathrm{H}}_8\mathrm{O}$.
• It is a white liquid with an anise-seed aroma, and both natural and synthetic scents frequently contain its derivatives.
• The substance, which is a precursor to other synthetic chemicals, is primarily synthesized.
• It is an ether.

Figure: Structure of Anisole

Alkylation of Anisole :

• The following reaction is followed as the alkylation of Anisole,

Nitration of Anisole :

• The following reaction is followed as the Nitration of Anisole,

Bromination of Anisole in Ethanoic acid medium :

• The following reaction is followed as Bromination of Anisole in Ethanoic acid medium,

Acetylation of Anisole :

• The following reaction is followed as Acetylation of Anisole,