Difference between Substitution, Insertion and Deletion Mutations

Mutations

Mutation is a change in base pairs or nucleotide sequence of a genome. Errors that occur during DNA replication or even exposure to radiation can cause such changes in the DNA sequence. This change or mutation causes genetic variation, which eventually leads to evolution. The following are the different types of mutations –

Substitution

This mutation is caused due to chemicals or any errors in DNA replication. Typically, a purine is substituted with another purine or pyrimidine with another pyrimidine. This type of substitution mutation is called transition. If purine is substituted for a pyrimidine or vice versa, it is called transversion substitution.

Insertion

The addition of one or more nucleobases can cause this type of mutation. It can cause frameshift mutation or sometimes even alterations in the mRNA. Both will eventually affect the final gene product. Insertions are usually provoked by transposable elements (TE). Thus, removal of TE can reverse insertions.

Deletion

Removal of one or more nucleobases is called a deletion mutation. This mutation can also change the reading frame (frameshift mutation). Moreover, deletions are highly unlikely to be reversed.

Also Read: The Molecular Basis of Mutation

Difference between Substitution, Insertion and Deletion Mutations

Substitution

Insertion

Deletion

It is a type of mutation where a nucleobase is replaced by another one.

It is a type of mutation where nucleotides are added/inserted into the DNA sequence.

It is a type of mutation where the nucleotides are removed/deleted from the sequence.

It causes base substitution or point mutation.

It causes frameshift mutation.

It causes frameshift mutation.

Explore: Mutation- A Genetic Change

Frequently Asked Questions on Difference between Substitution, Insertion and Deletion Mutations

What are chromosomal translocations?

A chromosomal translocation leads to unusual arrangements of chromosomes. It is a type of large-scale mutation where the exchange of genetic parts between non-homologous chromosomes occurs.

What are transposable elements?

Transposable elements (TE) are a type of mobile genetic element that can move freely within a genome. TE are a sequence of DNA that can alter its position within the nucleotide sequence. They can create as well as reverse mutations.

What is a frameshift mutation?

A frameshift mutation is typically caused by the deletion or insertion of nucleotides. This mutation shifts the reading frame, and thus alters the grouping of codons. A reading frame is nothing but the division of nucleotides into a triplet sequence.

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