What is Stereochemistry?

Stereochemistry is the branch of chemistry that involves the study of the different spatial arrangements of atoms in molecules. The structure of a molecule can vary based on the three-dimensional arrangement of the atoms that constitute it. Stereochemistry also deals with the manipulation of the arrangement of these atoms.

This branch of chemistry is commonly referred to as 3-D chemistry since it focuses on stereoisomers (chemical compounds with the same chemical formula but a different spatial arrangement in three dimensions).

Stereochemistry can trace its roots to the year 1842 when the French chemist Louis Pasteur made an observation that the salts of tartaric acid collected from a wine production vessel have the ability to rotate plane polarized light, whereas the same salts from different sources did not have this ability. This phenomenon is explained by optical isomerism.

One of the branches of stereochemistry deals with the study of molecules that exhibit chirality, which is a geometric property of molecules which make them non-superimposable on their mirror images.

Another branch of 3-D chemistry, known as dynamic stereochemistry, involves the study of the effects of different spatial arrangements of atoms in a molecule on the rate of a chemical reaction.


Stereoisomerism refers to the isomerism that is caused by the non-similar arrangements of atoms or functional groups belonging to an atom in space. These types of isomers have the same constitutions, but different geometric arrangements of atoms.  Stereoisomers can be broadly classified into two types, namely enantiomers and diastereomers.


  • When two isomers are mirror images of each other, the type of isomerism is called enantiomerism and these isomers are referred to as enantiomers.
  • Enantiomers are the stable and isolable compounds that differ in their spatial arrangements in 3-D space.
  • They generally exist as discreet pairs.
  • The properties of enantiomers are identical. However, their interaction with a plane of polarized light can vary.
  • The direction in which they rotate the plane polarized light is different, that is, if one rotates in right direction, the other rotates towards the left.


  • When two isomers do not behave as mirror images of each other, they are called diastereomers.
  • A molecule with ‘n’ number of asymmetric carbon atoms can have up to ‘2n’ diastereomers.
  • When two diastereomers differ at only one stereocenter, they are referred to as epimers.
  • These isomers vary in physical properties and chemical reactivity.

An illustration of enantiomers that are mirror images of each other is provided below.

Enantiomers in Stereochemistry

Importance of Stereochemistry – The Thalidomide Disaster

The arrangement of the atoms in three-dimensional space plays a crucial part in the properties of the molecule. An example of the significance of stereochemistry can be observed in the thalidomide disaster that struck Germany in the year 1957. The drug thalidomide was sold as an over-the-counter drug, initially intended to combat nausea. It was used by pregnant women to alleviate morning sickness.

However, it was discovered that the drug underwent racemization and formed a mixture of enantiomers in the human body due to the process of metabolism. One of these enantiomers is believed to cause genetic damage in developing embryos and lead to birth defects in babies.

This is based on the data that over 5000 babies were born with deformed limbs shortly after thalidomide was commercially sold as an over-the-counter drug. This unforeseen effect of the drug led to the imposition of stricter drug regulation laws (only 40% of the babies born with these deformities survived). The disaster signifies the importance of stereochemistry.

Thus, an introduction to the branch of chemistry known as stereochemistry is provided in this article. To learn more about stereoisomerism and other types of isomerism, register with BYJU’S and download the mobile application on your smartphone.

Practise This Question

In a college, the ratio of the number of boys to girls is 8 : 5. If there are 200 girls, the total number of students in the college is: