Relationship between Tissue Fluid and Lymph

Tissue Fluid

Tissue fluid, also known as interstitial fluid, is the fluid running between cells and blood capillaries in a tissue or an organ. It is very much similar to plasma and makes up the extracellular fluid, along with plasma. Its composition is water, amino acids, fatty acids, salts, sugars, hormones, coenzymes, white blood cells and metabolic waste products. All the nutrients and minerals are pushed out from the capillaries into the tissue fluid, and later taken up by the cells in the tissues.


Lymph is a fluid flowing through the lymphatic system consisting of lymph vessels and lymph nodes. It functions to bring fluids back from the tissues into the central circulation. It has a similar composition as tissue fluid. The tissue fluid, when entering the lymphatic system is known as lymph.

Read about lymph in detail here.

Let us look at the differences between tissue fluid and lymph.

Tissue Fluid



It is part of the extracellular fluid which flows between the blood vessels and cells.

It is a clear fluid draining out through the lymphatic system.


It is found in the spaces between the tissues and cells.

It is found in the lymphatic vessels.


It helps in transport of nutrients to the tissues and removal of wastes from the cells.

Its function is to remove metabolic and infectious wastes from the tissues.


It does not have fats.

It contains fats absorbed through the lacteals from the intestines.


In simple words, the tissue fluids collect the wastes from the tissues, pour it into the lymphatic ducts from where it goes back into the central circulation.

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Frequently Asked Questions

What is the difference between lymph and tissue fluid?

The main difference between lymph and tissue fluid is their location. While lymph is found in the lymph vessels, tissue fluid is found in the spaces between cells.

What is the relationship between blood tissue fluid and lymph?

Tissue fluid collects waste from the tissues and as it starts to accumulate in the interstitial spaces, lymphatic vessels pick up the fluid and return it to the central circulation.

What makes lymph fluid move through the body?

Lymph vessels work under low pressure and have a number of valves for the movement of lymph fluid.

How is lymph formed?

Lymph is formed when the extra interstitial fluids are collected in the lymphatic ducts.

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