Major Histocompatibility Complex is also known as MHC. MHCs are essential for adaptive immunity. They are required to present antigen for the recognition by T cells. They are a set of genes coding for the surface proteins required to identify foreign antigens. In humans, the HLA (Human leukocyte antigen) complex works similar to MHC. There are two classes of MHC complex – Class I and Class II. Read on to explore the differences between these two classes:
| Present on almost all cells which have a nucleus | Has a comparatively limited distribution. Typically found in dendritic cells, macrophages, and B-cells |
| HLA-A, HLA-B and HLA-C | HLA-D |
| Endogenous origins | Derived from extracellular proteins |
| Cytosolic Proteasome | Lysosomal and endosomal proteases |
| Endoplasmic Reticulum | Specialized Vesicular compartment |
| Presence of abundant antigens targets the cell for destruction | Presence of foreign antigens induce the production of antibodies |
| Recognized by CD8+ receptor of cytotoxic T cell | Recognized by CD4+ receptor of helper T cell |
Related Links:
- More Difference Between
- Proteins An Overview of its Structure Functions and Synthesis
- Explore About Immunity And Immune System In Detail
Explore more fascinating topics by registering at BYJU’S Biology
Comments