Chromosomal theory of Inheritance came into existence long after Mendelian genetics. During Mendel’s experimentation, the society was not acceptable to such drastic changes in their scientific ideas. They could not believe the existence of such discrete factors such as genes which would segregate without mixing as this did not support their idea of the constant changes leading to evolution. Moreover, the means of communication was poor at that time as a result of which, the information could not be conveyed to the masses. Also, Mendel’s mathematical approach to prove biological laws was unacceptable. As time passed, scientists Vries, Correns and Tschermak discovered chromosomes which existed inside the nucleus. Sutton and Boveri discovered observed the behavior of the chromosomes when the cells divided. With the advancements in microscopy, this task became easier. They proved Mendel’s laws with the help of chromosomal movement. They showed the segregation of the chromosomes during the Anaphase of cell division. The idea of chromosomal segregation combined with the Mendelian principles gave rise to the chromosomal theory of Inheritance. The work was further carried forward and proved by T.H. Morgan, who used Drosophila melanogaster to show how sexual reproduction gave rise to variations.
Chromosomal theory: Linkage and genetic recombination
Morgan observed that while crossing a set of characteristics, two genes did not segregate as per Mendel’s law. If two genes were present on the same chromosome, the probability of getting a parental combination was much higher in the next generation compared to the non-parental combination. This physical association of genes was termed as linkage. The term genetic recombination described the non-parental gene combinations in a dihybrid cross. Once, linked genes were discovered, the frequency of linked genes also influenced the appearance of traits in the next generation. A student of Morgan, Sturtevant discovered the position of linked genes on a chromosome by calculating their frequency of genetic recombination by the process of gene mapping. This method of generating link map was extensively used during the Human Genome Project.
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