The induced immunity in organisms by the exposure of antigens is known as the active immunity. The active immunity is mediated by two distinct mechanisms known as Cell-mediated Immunity and Humoral Immunity. These two immunity pathways show a considerable amount of differences in their targets, components and the method of killing pathogens. The difference between humoral and cell-mediated immunity is given below in a tabular column.
Humoral vs Cell-Mediated Immunity
|Humoral Immunity||Cell-mediated Immunity|
|Humoral immunity is a component of adaptive immunity in which the B cells secrete antibodies that circulate as soluble proteins in the blood||Cell-mediated Immunity is another component of adaptive immunity that is activated by the antigen-specific T cells|
|Antibodies are present||Antibodies are absent|
|Protects against extracellular pathogens||Protects against intracellular pathogens|
|Rapid onset||Delayed onset|
|It is mediated by B cells, T cells and macrophages||Mediated by cytotoxic T cells, helper T cells, macrophages and natural killer cells|
|Plasma B cells secrete antibodies||T cells secrete cytokines|
These were a few differences between humoral and cell-mediated immunity. The main difference between humoral immunity and cell-mediated immunity is that antibodies specific to antigens are produced in humoral immunity whereas antibodies are not produced in cell-mediated immunity.