Difference Between Humoral and Cell-Mediated Immunity

The induced immunity in organisms by the exposure of antigens is known as active immunity. The active immunity is mediated by two distinct mechanisms known as Cell-mediated Immunity and Humoral Immunity. These two immunity pathways show a considerable amount of differences in their targets, components and the method of killing pathogens.

Humoral Immunity

Humoral immunity is mediated through antibodies. It shows a quick response against pathogens. It is the major defence mechanism against extracellular microbes trying to invade the host systems. The antibodies produced by the B-cells bind to the antigens and neutralize the microbes.

Cell-Mediated Immunity

Cell-mediated immunity is facilitated by the T-helper and cytotoxic T-cells. Cytokines secreted by the T- helper cells activate phagocytic cells which phagocytosis the pathogens and kill them.

Difference Between Humoral and Cell-Mediated Immunity

The difference between humoral and cell-mediated immunity is given below in a tabular column.

Cell-mediated Immunity Humoral Immunity
Cell-mediated response is mediated by antibodies. Humoral response is mediated by antibodies.
Antibodies are not formed here. Antibodies are formed here.
Receptors are used to detect antigens. Antibodies are used to detect antigens.
It protects against intracellular bacterial and viral pathogens. It protects against extracellular bacterial and viral pathogens.
T helper, T cytotoxic and natural killer cells are involved in cell-mediated immunity. T-cells, B-cells and macrophages are involved in humoral immunity.
It mediates delayed hypersensitivity. It mediates immediate hypersensitivity.
It can eliminate tumor cells. It cannot eliminate tumour cells.
It participates in rejection of organ transplants. It might be involved in early graft rejection.
CD4+ and CD8+ cells are involved in cell-mediated immunity. Only TH cells are involved in humoral immunity.

These were a few differences between humoral and cell-mediated immunity. To know more about the difference between humoral and cell-mediated immunity, keep visiting BYJU’S website or download BYJU’S app for further reference.

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