Difference Between Endotoxins And Exotoxins

The basic difference between Endotoxins and Exotoxins lies in the way how these are produced by bacteria. “Endotoxin”, as the name suggests, is the toxin that are liberated from the outer cell wall of a bacteria upon its death. Meanwhile, “Exotoxins” are produced inside the bacteria itself as a part of their metabolism.

Difference Between Endotoxins And ExotoxinsExotoxins

These toxins widely vary in toxicity and lethality. But Exotoxins are much more potent and often fatal when compared to endotoxins. The deadliest toxin in the world – Botulinum toxinor Botox is produced by the bacterium Clostridium botulinum. The other major difference between Endotoxins and Exotoxins are summarized below:

Difference Between Endotoxins And Exotoxins

Exotoxins

Endotoxin

The toxin is excreted as a part of metabolism

The toxin forms a part of the cell wall and is released upon the death of the bacteria

Toxin is composed of polypeptides

Toxins is composed of a Lipoglycan complex

It has the ability to trigger an immune response

It’s ability to trigger an immune response is comparatively weaker

Quite unstable

Comparatively more stable

Extremely toxic and often fatal in larger quantities

Moderate toxicity

Can be made into a Toxoid (non toxic version of toxins with antigenic properties)

Cannot be more into toxoids

Gets denatured on boiling

Does not get denatured

Examples of exotoxin producing bacteria are Clostridium botulinum (Botox), Clostridium tetani (Tetanus), Corynebacterium diphtheriae (Diphtheria)

Examples of endotoxin producing bacteria are Salmonella typhi (Typhoid), Vibrio cholerae (Cholera)

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