Difference Between Hypertrophy And Hyperplasia

The terms hypertrophy and hyperplasia explain the growth abnormalities in living tissues. The tissues grow out of the normal under excessive or abnormal stimulations. There are many differences between hyperplasia and hypertrophy, being two different pathological entities.

The difference between hypertrophy and hyperplasia are given below in a tabular column.

Hyperplasia Vs Hypertrophy

Hyperplasia Hypertrophy
Increase in the amount of a tissue due to cell proliferation. Increase in the volume of an organ or a tissue due to the enlargement of cells
Occurs in labile cells or stable cells Occurs in permanent cells
Provoked due to excessive cell stimulation Provoked due to increased demand
Increases the size of the tissue by cell division. Stromal and cellular components are enlarged by increasing their size without multiplying

What is Hyperplasia?

Hyperplasia is the increase in the amount of tissue due to cell proliferation. It might lead to the enlargement of a certain organ. It is a common response to a stimulus. The cell does not proliferate in the absence of the stimulus. The cells undergoing hyperplasia are controlled by growth hormones.

What is Hypertrophy?

Hypertrophy refers to the increase in the volume of a given tissue or organ occurring only in permanent cells. Hypertrophy can be of two types – physiological or pathological.

From the differences, we can conclude that hyperplasia is the increase in the size of a tissue or an organ due to an increased number of cells while hypertrophy is an increase in the size of an organ due to the swelling of individual cells.

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4 Comments

  1. Thanks Sir/Madam
    I got my answer.

  2. what is permanent cell or tissue ?

    1. The tissues that are completely grown and have lost the ability of division are known as permanent tissues. Read more about permanent tissues here.

    2. Permanent cells are those cells which lose their ability to proliferate around the time of birth. These includes neurons of nervous system, skeletal muscle and cardiac muscle cells.

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