Difference between Serum and Plasma

Blood is a fluid connective tissue which travels throughout the body by transporting all the necessary elements like nutrients, oxygen, and other metabolic wastes. It is also involved in the regulation of the body’s temperature and the pH by interacting with acids and bases.

Blood is largely composed of RBC – red blood cells, WBC -white blood cells, plasma, and serum. Both plasma and serum are the main components of blood and are routinely used in blood group test experiments for determining the patient’s blood group.

Plasma and serum can be separated by centrifugation of blood on the basis of weight, size, and density. The serum is obtained after blood clotting whereas plasma is obtained after blood coagulation.

Also Read: Difference between blood and lymph

What is Plasma?

Plasma is the medium of the blood, in which different types of blood cells including red blood cells, white blood cells and other components of blood are suspended.

Plasma is the liquid part of the blood. It contains the clotting agent fibrinogen which prevents excessive flow of blood during injury. It also contains proteins which help in the transportation of glucose and other nutrients to different parts of the body.

Plasma helps in the regulation of body temperature and controlling blood pressure.

Plasma is obtained in the upper layer during centrifugation. It is separated to increase the longevity up to years and also to make it easier to carry it from one place to another.

What is Serum?

The serum is the liquid or undiluted part of the blood which lacks clotting factors. Hence it is formed after the coagulation of the blood.

It helps in the diagnosis of diseases such as blood pressure, sugar, cholesterol, etc.

Here are some great differences between the two main components of blood cells – Plasma, and Serum.

Difference between Plasma and Serum

Following are the important difference between plasma and serum:

Plasma Serum
A clear, straw-coloured, liquid portion of the blood. An undiluted fluid, the extracellular portion of blood.
Composed of serum and clotting factor. It is the part of the blood which lacks clotting factor.
Acquired after centrifuging blood with the anticoagulant. Acquired after centrifuging of coagulated blood.
Anticoagulant is required to obtain plasma from the blood sample. Anticoagulant is not required to separate the serum from the blood sample.
Consists of 55% of the total volume of blood. Less volume in comparison to plasma.
Comparatively easier and less time is required to separate the plasma from the blood sample. Difficult to separate serum from the blood sample. It is a time-consuming process.
Contains fibrinogen. Lack of fibrinogen.
Consists of 92% water with Proteins, Salts, Lipids, and Glucose. Consists of 90% water with dissolved hormones, proteins, minerals, and carbon dioxide.
Has 1.025 g/ml density Has 1.024 g/ml density.
Have more shelf life. It preserved even for 10 years. Have less shelf life. It can be preserved only for a few months.
Plasma is the main medium for excretory product transportation. An important source of electrolytes.
Cells are freely suspended in plasma. Cells are attached together by clot formation.

Also Read: Body fluids and circulation

For more information on Plasma, serum and the difference between plasma and serum, keep visiting BYJU’S website or download BYJU’S app for further reference.

Frequently Asked Questions

What are the advantages of plasma over serum?

Plasma contains the most commonly used anticoagulant heparin. It acts through a complex it forms with anti-thrombin-III. Anti-thrombin III is a protein that prevents blood clotting.

What is a serum?

Serum is the plasma from which the clotting factors have been removed.

What is the difference between blood and plasma?

Plasma is the translucent part of blood other than RBCs, WBCs, platelets and other cellular components. It helps to clot blood and is composed of 90% water.

How is the plasma collected from the body?

Collection of plasma requires a lot of time. It takes around an hour to collect plasma from the body. The blood is drawn from the body with the help of a needle placed in the arm and the plasma is separated from the red blood cells, white blood cells and platelets.

Why is the serum test conducted?

The serum is done to measure the amount of protein albumin in the blood. When the starts to fail the albumin starts leaking in the urine. The serum test helps to diagnose liver and kidney abnormalities.

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