Fertilization And Implantation

Fertilization and implantation are the most important events in the reproduction process. The egg and sperm fuse together to form a zygote which gets implanted into the uterus and the development of an organism begins.

Let us have a look at how fertilization and implantation take places in humans.

Fertilization and Implantation

The diagram representing the Process of Fertilization and Implantation

Fertilization in Humans

Fertilization is the biological process of fusion of male and female gametes resulting in the formation of a zygote. The fertilization in humans takes place in the fallopian tube.

In this process, semen containing thousands of sperms is inseminated into the female vagina during coitus. The sperms move towards the uterus but not all succeed in reaching the opening of fallopian tube.

The secondary oocyte releases from the mature Grafian follicle of the ovary. It enters into the fallopian tube. It can be fertilized within 24 hours after it is released from the ovary.

Though surrounded by several sperms, the oocyte is fertilized by a single sperm. During meiosis-II the sperm enters the secondary oocyte and completes the meiosis. After this, the secondary oocyte is known as the egg.

Both sperm and egg can show their vitality only to a limited period of time. Sperm is alive for 48-72 hours in a female reproductive system whereas the egg can be fertilized until 24 hours from its release. 

Also Read: Internal and External Fertilization

Steps of Fertilization in Humans

The fertilization in humans takes place in several steps involving chemical and physical events. The different steps of fertilization in humans are mentioned below:

Acrosomal Reaction

The sperms in capacitation undergo acrosomal reactions and release certain chemicals known as sperm lysins present in the acrosome.

Due to the acrosomal reactions, the plasma membrane of the secondary oocyte and the sperm fuse together so that the contents of the sperms can enter. When the plasma membrane of the sperm binds with that of the secondary oocyte, the plasma membrane of the oocyte depolarizes. This prevents polyspermy.

Calcium ions play a major role in the acrosomal reaction. The main factors essential for acrosomal reactions are optimum pH, temperature and calcium and magnesium on concentration.

Cortical Reaction

Soon after the fusion of the plasma membranes, the oocyte shows cortical reactions. Cortical granules are found under the plasma membrane of the oocyte which fuses with the plasma membrane and releases cortical enzymes between the zona pellucida and plasma membrane. The zona pellucida is hardened by the cortical enzymes that prevent polyspermy.

Sperm Entry

A projection known as the cone of reception is formed by the secondary oocyte at the point of sperm contact. This cone of reception receives the sperm.


After the entry of the sperm, the suspended second meiotic division is completed by the secondary oocyte. This gives rise to a haploid ovum and a second polar body.

The head of the sperm containing the nucleus detaches from the entire sperm and is known as male pronucleus. The tail and the second polar body degenerates. The nucleus of the ovum is known as female pronuclei.

The male and female pronuclei fuse together and their nuclear membranes degenerate. The fusion of the chromosomes of male and female gametes is called karyogamy. The ovum is now fertilized and is known as a zygote.

 Activation of Eggs

The entry of sperm triggers the metabolism in the zygote. Consequently, protein synthesis and cellular respiration increase.


Once fertilization happens, the cell starts to divide and multiply within 24 hours at the fallopian tube. This detached multi-celled structure is called zygote. Later, after 3-4 days it travels to the uterus and now we call it as an embryo.

The embryo develops and undergoes various stages and gets attached to the endometrial layer of the uterus. This process of attachment is known as implantation. 

Sex determination

Fertilization is the process in which a new cell is formed when two gametes (sex cells) –sperm and ova fuse together. During this unbiased event, all genetic information is transferred from both the parents to their child and the gender of the child is determined.

Father determines the sex of the child i.e. if the sperm carries a Y chromosome, the child will be a boy; if sperm carries X chromosome child will be a girl.

Also Read: Implantation

For more information on Fertilization and Implantation, and steps of fertilization in humans, keep visiting BYJU’S website or download BYJU’S app for further reference.

Frequently Asked Questions

What is human fertilization?

The fusion of male and female gametes occurring in the ampulla of the fallopian tube is known as fertilization in humans.

How long does it take for the egg to get fertilized?

The egg is alive for about 12-24 hours after its release from the ovary. If it is not fertilized by this time, it disintegrates and is shed off by the uterine lining.

How long does sperm live?

The sperm stays alive for about 72 hours. The sperms swim upwards to the fallopian tube to fertilize the egg. The faster the sperm swims, the earlier it reaches the egg.

What are the different phases of fertilization?

The different phases of fertilization include- penetration, where the sperm releases acrosomal enzymes to penetrate inside the egg; activation, where the egg membrane depolarizes; and fusion of nuclei and formation of zygote.

What is the sole purpose of fertilization?

The main purpose of fertilization is to combine the haploid chromosome sets of two individuals into a single diploid cell known as the zygote which is the result of activation of the egg.

What are the different types of fertilization?

There are two different types of fertilization- internal fertilization, where the fusion of egg and sperm occurs inside the female reproductive tract, for eg., humans; and external fertilization, where the fusion of male and female gametes occurs outside the body of the organism, for eg., sea urchins, frogs, etc.

What would happen if fertilization does not occur?

If fertilization does not occur, there will be no zygote formation and egg will degenerate and shed through the uterine lining.

What is implantation?

Implantation is the stage where the embryo adheres to the wall of the uterus.

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