Amino Acid Structure

What is the General Molecular Structure of an Amino Acid?

Amino acids are organic compounds that combine to form proteins. The general formula of an amino acid is R-CH(NH2)-COOH. Amino acids are known to contain amine and carboxyl functional groups. They also contain a side chain that is made up of an R-group (where ‘R’ can denote any alkyl or aryl group). These R-groups are what differentiate amino acids and are responsible for their unique properties. The general structure of an amino acid is illustrated below.

Amino Acid Structure

From the illustration, it can be noted that the key elements that make up amino acids are hydrogen, carbon, nitrogen, and oxygen. However, it is not uncommon for other elements to be found in the side chain of an amino acid. It can also be noted that there are over 500 naturally occurring amino acids known to us. Of these, only 20 amino acids are known to appear in genetic code.

In the human body, these biomolecules are involved in many biological and chemical functions and are important ingredients for human growth and development. Amino acids usually have a melting and boiling point that is very high. They usually exist in the form of white, crystalline, stable compounds. A few amino acids are known to be sweet, tasteless, and bitter in flavour. Most amino acids are water soluble. However, it can also be noted that most amino acids are insoluble in organic solvents.

Some Common Amino Acids and Their Structures

The structures of some common amino acids, such as glycine, serine, leucine, cysteine, and valine have been illustrated below.

Structure of Amino Acids

Glycine

Glycine is an amino acid that contains, in its side chain, only a single hydrogen atom. It is known to be the simplest amino acid with the chemical formula NH2-CH2-COOH (because carbamic acid is known to be unstable). Glycine is known to be a protein-genic amino acid. Glycine, due to its compact shape, is integral to the formation of alpha-helices in the secondary protein structure. For the same explanation, in collagen triple-helices, it is the most abundant amino acid. It is important to note that glycine is an inhibitory neurotransmitter. Because of uninhibited muscle contraction, interference with its release inside the spinal cord, such as in clostridium tetani infections for example, can trigger spastic paralysis.

Serine

Serine is an alpha-amino acid which is often used in protein biosynthesis. It comprises an alpha-amino group which, under biological conditions, is in the protonated -NH3+ form. It also contains a carboxyl group which, under biological conditions, is in the deprotonated -COO form. Serine is also known to contain a side chain consisting of a hydroxymethyl group and can, therefore, be classified as a polar amino acid. Under normal physiological conditions, it can be synthesised in the human body, rendering it a nonessential amino acid.

Leucine

Leucine is an important amino acid which is used in protein biosynthesis. Leucine is an alpha-amino acid, which implies that it contains an alpha-amino group (which, under biological conditions, is in the protonated -NH3+ form), an alpha-carboxylic acid group (which, under biological conditions, is in the deprotonated -COO form), and a side chain isobutyl group, making it a non-polar aliphatic amino acid. In human beings, it is an essential amino acid, implying that it can not be synthesised by the body. It must, therefore, be derived from the diet. The foods that produce protein, such as dairy products, meats, beans, soy products, and other legumes are human dietary sources of this amino acid.

Cysteine

Cysteine is a proteinogenic amino acid which is generally categorized as a semi-essential amino acid. Since it functions as a nucleophile, the thiol side chain in this amino acid also participates in several enzymatic reactions. The disulfide derivative cystine, which is known to play an essential structural role in a large number of proteins, is known to be susceptible to oxidation by thiol. Cysteine has the general same structure as serine, but with one of its oxygen atoms substituted by sulphur. Selenocysteine can be obtained by replacing the same oxygen atom with selenium instead of sulfur.

Cysteine, along with its oxidised dimeric form, cystine, like other common amino acids, can be found in most high-protein foods. While it is listed as a non-essential amino acid, cysteine can be essential in some rare cases the elderly, for children, and people with certain metabolic disorders or those who have syndromes of malabsorption. Under normal physiological conditions, cysteine is normally synthesised by the human body as long as an adequate quantity of methionine is available in it.

Valine

Valine is an important amino acid which is used in protein biosynthesis. Valine is an alpha-amino acid, which implies that it contains an alpha-amino group (which, under biological conditions, is in the protonated -NH3+ form), an alpha-carboxylic acid group (which, under biological conditions, is in the deprotonated -COO form), and a side chain containing the isopropyl group. It can, therefore, be referred to as a non-polar aliphatic amino acid.

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Frequently Asked Questions on Amino Acid Structure

What are amino acids?

Amino Acids are the organic compounds which combine to form proteins. They are, therefore, referred to as the building components of proteins. These biomolecules are known to be involved in several biological and chemical functions in the human body. They are very important ingredients for the growth and development of human beings.

List 5 examples of amino acids.

5 examples of amino acids are: Valine, Cysteine, Leucine, Serine, and Glycine.

What are the plant-based sources of amino acids?

Plant-based sources of amino acids include beans, broccoli, pumpkin, dry fruits, and legumes

What is the function of valine in the human body?

Valine is known to act as an important component in promoting muscle growth in the human body.

What is the function of lysine in the human body?

Lysine is known to be necessary for promoting the formation of antibodies, enzymes, and hormones in the human body. It is also vital for the development and fixation of calcium in bones.

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