What is Histidine?
Histidine is an essential amino acid that plays a vital role in the biosynthesis of proteins. It comprises a carboxylic acid group, α-amino group, and an imidazole side chain thus labeling it into a positively charged amino acids in terms of physiological pH.
Histidine Chemical Properties
Histidine is evident as it comprises of the ring structure in its ‘R’ group consisting of 2 nitrogen group.
Chemical Structure: C6H9N3O2
Abbreviation used to represent this essential amino acid is either ‘His’ or ‘H’. They are generally positively charged.
Biochemistry: Imidazole chain is an element of catalytic sites found in certain enzymes and it is one of the most prevalent coordinating ligands in metalloproteins. In Order to activate it as a nucleophile in catalytic triads, basic nitrogen of histidine are used to abstract a proton from a cysteine, threonine, and serine. Whereas in case of proton shuttle, it is used to shuttle protons.
Aromaticity: At each level of ph value, imidazole ring of histidine is aromatic. It comprises of 6 pi electrons among which 2 form a nitrogen lone pair and four form 2 double bonds. It can possibly lead to the formation of pi-stacking interactions but it is hard due to positive charges.
- L-Histidine is a vital amino acid that is needed by the body mainly in the growing stage of the children. Hence, it is present in means of supplementary or in food.
- Various food products that include histidine are fish, meat and dairy products.
- It is helpful in transferring a large amount of iron and copper.
- It controls diarrhea as it boosts absorption of calcium thus decreasing the histidine level. But excessive consumption would lead to some side effects such as constipation.
- It has a symbolic mechanism in preventing internal bleeding and clotting of blood.
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