Reaction due to α-hydrogen

Every student of Chemistry would have used the term Hydrogen on countless occasions. Here, we will be discussing the various reactions due to alpha-hydrogen in the coming lines.

Reaction due to α hydrogen

Due to the acidic nature of α-hydrogen of aldehydes and ketones, they undergo a number of reactions. This acidity is because of the strong electron-withdrawing nature of the carbonyl groups and resonance stabilisation of the conjugate base.

  • Aldol condensation: β-hydroxy aldehydes and β-hydroxy ketones are produced when aldehydes and ketones having one α-hydrogen undergoes a reaction in the presence of dilute alkali as a catalyst. The name Aldol is derived from the names of two functional groups, aldehydes and alcohols. Water is lost by both Aldol as well as ketol to give α, β-unsaturated carbonyl compounds which are the products of aldol condensation and this reaction is called aldol condensation.
  • Cross aldol condensation: When two different aldehydes and ketones are involved in aldol condensation then it is called cross aldol condensation. We get a mixture of four products if both of them contain an α-hydrogen.
  • Cannizzaro reaction: When heated with an alkali, aldehydes and ketones should not contain any alpha hydrogen atoms, and undergoes self-oxidation and reduction reaction. One molecule in this reaction is oxidised to form acid and one molecule is reduced to form alcohol
  • Electrophilic substitution reaction: In-ring aromatic ketones and aldehydes, undergo an electrophilic substitution reaction in which the carbonyl group acts as a deactivating group.

Uses of aldehydes and ketones:

  • For the synthesis of different products, aldehydes and ketones are used as solvents, reagents and starting materials.
  • For the preservation of biological specimens, preparation of bakelite and many more, we use formaldehyde which is also known as formalin.
  • For the manufacture of acetic acid, ethyl acetate and acetaldehydes.
  • Benzaldehyde is used in making perfumes and in dry industries.
  • Some common industrial solvents are acetone and ethyl methyl ketones.
  • Acetophenones, camphor and vanilla are some aldehydes and ketones that are used for flavour and colour.

From the above discussion, one could easily state that hydrogen has many applications for different industries and this is one of the main reasons why chemists around the world are conducting research on how to use α-hydrogen better in the coming years.

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