29 September 2023 CNA
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TABLE OF CONTENTS
A. GS 1 Related B. GS 2 Related C. GS 3 Related ECONOMY 1. Architect of India’s Green Revolution departs D. GS 4 Related E. Editorials SOCIAL ISSUES 1. Reform can address India’s kidney transplant deficit F. Prelims Facts 1. Monoclonal antibodies 2. Current Account Deficit G. Tidbits 1. Toto language H. UPSC Prelims Practice Questions I. UPSC Mains Practice Questions
A. GS 1 Related
Nothing here for today!!!
B. GS 2 Related
Nothing here for today!!!
C. GS 3 Related
1. Architect of India’s Green Revolution departs
Syllabus: Indian Economy and issues related to agriculture, food security, and sustainable farming practices.
Mains: Green Revolution- Its characteristics, benefits and disadvantages.
Prelims: Green Revolution and M S Swaminathan
Context
M.S. Swaminathan, the pioneering agricultural scientist behind India’s Green Revolution, passed away at 98. His life, contributions, and legacy are commemorated below.
Introduction
- M.S. Swaminathan, the renowned agricultural scientist, passed away in Chennai at the age of 98.
- He played a pivotal role in India’s Green Revolution, a program that transformed agriculture.
Read more about Mankombu Sambasivan Swaminathan.
Career Highlights
- Joined the Central Rice Research Institute (CRRI) and Indian Agricultural Research Institute (IARI).
- Became Director of IARI in 1966, where he gained fame.
- Received the Padma Shri in 1967 and the Ramon Magsaysay award in 1971.
- Appointed Director-General of the Indian Council of Agricultural Research (ICAR) in 1972.
- Served as Principal Secretary, Union Ministry of Agriculture and Irrigation.
- Played a role in the International Rice Research Institute (IRRI) in the Philippines.
- For his contributions, he was awarded the first World Food Prize Laureate in 1987
- Established the M.S. Swaminathan Research Foundation (MSSRF) in India in 1988.
- Dr. Swaminathan served as a nominated member of the Rajya Sabha from 2007 until 2013.
- He received the inaugural World Agriculture Prize, established by the Indian Council of Food and Agriculture, in the year 2018.
Contributions
- Background:
- Consecutive severe droughts during the mid-1960s necessitated the political leadership and the scientific community to seek solutions to break free from the cycle of food scarcity.
- At that time, India heavily relied on importing food grains from the United States, particularly PL480 wheat.
- In 1966, another harsh drought year, India imported a staggering 10 million tonnes of PL480 wheat.
- Dr. Swaminathan collaborated closely with two Agriculture Ministers, C. Subramaniam (1964-67) and Jagjivan Ram (1967-70 & 1974-77), in driving the success of the Green Revolution. This initiative marked a significant leap in wheat and rice production and productivity, achieved through the adoption of chemical-biological technology.
- Green Revolution:
- The Green Revolution brought about a dramatic transformation in India’s agriculture sector by providing high-yielding variety seeds, improved irrigation, and fertilisers to farmers in Punjab, Haryana, and western Uttar Pradesh primarily. Initially implemented for rice, it was later expanded to include wheat production.
- In 1947, at the time of India’s independence, the annual wheat production stood at approximately 6 million tonnes. However, by 1962, it had increased to about 10 million tonnes per year. Between 1964 and 1968, there was a remarkable surge in wheat production, reaching around 17 million tonnes annually. This substantial increase in production marked a revolutionary breakthrough.
- Numerous researchers and scientists played crucial roles in this endeavour. Nevertheless, there is no doubt that the foundational strategic concept behind the Green Revolution in India, which involved introducing new genetic strains or ‘plant types’ responsive to increased fertiliser and water application, can be attributed to Swaminathan.
Read more on the father of the Green Revolution in India, M S Swaminathan.
- Evergreen Revolution:
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- Faced criticism for some negative consequences of the Green Revolution, including ecological damage and issues for small farmers.
- Swaminathan identified these concerns as far back as January 1968.
- He voiced the potential risks associated with the swift replacement of diverse locally adapted crop varieties with just a few high-yielding strains over extensive regions.
- He also cautioned against the intensive farming practices that neglected soil fertility conservation, warning that they could eventually result in the emergence of desert-like landscapes.
- Furthermore, he raised alarms about the indiscriminate application of pesticides, fungicides, and herbicides, along with the unscientific extraction of groundwater. These prophetic warnings have undeniably materialised in the present day.
- Swaminathan responded with the concept of the “evergreen revolution” to ensure sustainable agriculture.
- Swaminathan also led the National Commission on Farmers, known as the Swaminathan Commission.
- Recommended that minimum support price should be at least 50% more than production costs.
Nut Graf: M.S. Swaminathan’s demise marks the end of an era in Indian agriculture. His leadership in the Green Revolution and dedication to sustainable farming left an enduring impact on the nation.
D. GS 4 Related
Nothing here for today!!!
E. Editorials
1. Reform can address India’s kidney transplant deficit
Syllabus: Issues Relating to Development and Management of Social Sector/Services relating to Health
Mains: Organ Donation, Regulation of Kidney Transplant
Prelims: Chronic Kidney Disease, The Transplantation of Human Organs and Tissues Act 1994
Context
- India faces an alarming shortage of organs for transplantation, particularly kidneys.
Data
- In 2022, over 200,000 patients required a transplant, but only around 7,500 transplants were performed (approximately 3.4%).
- The transplant rate in developed countries like the US is around 20%, highlighting the disparity between India and these countries.
- The high prevalence of Chronic Kidney Disease (CKD) in India, affecting approximately 17% of the population, contributes to the demand for kidney transplants.
- CKD often progresses to end-stage renal disease (ESRD), making a kidney transplant the most effective treatment option.
- Transplants are preferred over alternative treatments due to their advantages in quality of life, patient convenience, life expectancy, and cost-effectiveness.
Read more about Chronic Kidney Disease (CKD).
State of the Kidney Transplant Ecosystem
- Patients have few options for obtaining a kidney:
1. Deceased donor transplant: Limited by lack of donations, specific requirements for nature of death, and infrastructure challenges.
2. Living related donor transplant: Restricted by compatibility requirements (blood type and tissue type) between donor and recipient, with many relatives and friends being incompatible. - Strict regulations in India, rather than a lack of medical facilities, contribute significantly to the gap in transplant rates.
- The current regulations need urgent reform to allow for two innovative kidney exchange methods: kidney ‘swaps’ and kidney ‘chains’.
Kidney Swaps and Kidney Chains
- Kidney swaps involve the exchange of kidneys between two strangers, while kidney chains involve a series of donations where each recipient’s relative donates a kidney to another recipient.
- Legal roadblocks are preventing these methods from being used effectively in India.
- For kidney swaps, the law currently allows only near-relatives to be donor-recipient pairs, but recent court judgments in Kerala, Punjab, and Haryana have allowed non-near-relative pairs after verification.
- There should be a national coordinating authority for swaps, like there is for direct transplants from cadavers, to create larger and more diverse pools of potential donors and recipients.
- Kidney chains are not happening in India because it is illegal to donate a kidney out of altruism in all states except Kerala.
- Harsh laws regulating swaps and chains have led to a proliferation of black markets for kidneys, which put desperate participants at risk.
Reforms are happening at a slow pace
- Reforms in kidney exchange laws have been slow in India.
- The Transplantation of Human Organs and Tissues Act 1994 recognized transplant possibilities from brain-stem death patients.
- The 2011 amendment legalized swap transplants and established a national organ transplant program, but the network remained underdeveloped.
- Transplantation of Human Organs and Tissues Rules 2014 gave the following provisions:
- The Authorization Committee deciding on the issue of transplant requires a minimum of four members, including the chairman, secretary (health), or appointee, and director of health services or appointee.
- When the donor and recipient are not related, the Authorization Committee ensures that there is no financial exchange between them.
- In cases of swap donation, the Authorization Committee of the hospital, district, or state where the transplant is planned must approve it, and the donation is only allowed from close relatives of the swap recipients.
- If the recipient needs a life-saving transplant urgently, the donor or recipient can ask the hospital in charge to speed up the Authorization Committee’s assessment.
- The Authorization Committee must make a final decision within 24 hours of the meeting and display it on the hospital’s notice board and website within 24 hours.
- An apex national networking organization will be established at the center, along with regional and state-level networking organizations.
- State units will be connected to hospitals, organ/tissue labs, and tissue banks within their region and to regional and national networking organizations.
- A National Registry on Donors and Recipients of Human Organs and Tissues will be created, accessible through a dedicated website with national, regional, and state-specific information.
- Recent government reforms (February 2023) relax age and domicile requirements for seeking organs, but they do little to address the underlying issue of insufficient kidney supply.
Also read National Organ and Tissue Transplant Programme (NOTP).
Way Forward
- Allowing and encouraging altruistic donation, non-near relative donation for swaps, and improving kidney exchange infrastructure would be beneficial.
- Other countries like Australia, Canada, Israel, the Netherlands, Spain, the UK, and the US have already set precedents for allowing altruistic donations and establishing national registries for kidney chains and swaps.
- India can adapt and learn from these successful regulations to improve the lives of its citizens.
Nut Graf: India faces a critical shortage of kidneys for transplantation, with only 3.4% of patients receiving transplants in 2022. Reforms are needed to allow for kidney swaps and chains, which could expand the donor pool and increase transplant rates.
F. Prelims Facts
Syllabus: GS 3- Science and Technology
Prelims: Monoclonal antibodies
Introduction
- India reached out to Australia for monoclonal antibodies to tackle the Nipah virus outbreak in Kerala.
- The Indian Council of Medical Research (ICMR) anticipates receiving 20 doses soon.
- In the Kozhikode district, the Nipah virus has claimed two lives and infected five others.
- Remarkably, this marks Kerala’s fourth Nipah outbreak since 2018.
- It’s important to note that, as of now, no one in India has received these antibodies because they are most effective when administered early in the infection.
Understanding Monoclonal Antibodies
- Monoclonal antibodies are laboratory-engineered proteins that mimic the immune system’s natural antibodies, safeguarding against diseases and foreign invaders.
- These antibodies attach themselves to specific antigens, typically disease-causing molecules, helping the immune system eradicate them.
- They are custom-designed to target particular antigens, a breakthrough for which the Nobel Prize in Medicine was awarded in 1984.
Meet m102.4: A Powerful Monoclonal Antibody
- m102.4 is a “potent, fully human” monoclonal antibody that effectively neutralises both Hendra and Nipah viruses, both within and outside living organisms.
- m102.4 has successfully passed phase-one clinical trials, where it was tested with a small group of individuals to determine the right treatment dosage that doesn’t cause side effects.
- Currently, this antibody is used on a ‘compassionate use’ basis, meaning it’s administered under strict conditions when no authorised alternatives are available, and patients can’t participate in clinical trials.
- Dr. Christopher Broder and his team at the Uniformed Services University of the Health Sciences (USU) in Bethesda, Maryland, developed m102.4 with support from the U.S. National Institutes of Health (NIH).
How Monoclonal Antibodies Function
- These antibodies are meticulously engineered to target specific diseases by binding to their unique antigens, usually proteins.
- A prime example is the successful development of monoclonal antibodies during the COVID-19 pandemic, which were engineered to bind to the spike protein of the SARS-CoV-2 virus, preventing it from infecting other cells.
- The technology for producing hybridoma cells, a fusion of B cells (which produce antibodies) and myeloma cells (abnormal plasma cells), was first established by Dr. Köhler and Dr. Milstein in 1975. This advancement allowed for the creation of monoclonal antibodies.
- Today, these antibodies are produced using recombinant DNA technology.
Also read Difference between COVID-19 and SARS.
Targeting the Nipah Virus with m102.4
- Glycoproteins are significant components of viruses causing diseases in humans.
- Research indicates that m102.4 monoclonal antibody binds to the immunodominant receptor-binding glycoprotein of the Nipah virus, potentially neutralizing it.
Insights from Phase One Clinical Trial
- A successful clinical safety trial was conducted involving 40 volunteers between March 2015 and June 2016 for monoclonal antibody m102.4.
- Dr. Geoffrey Playford from Princess Alexandra Hospital in Brisbane, Australia, led this groundbreaking study, which was the first human trial to assess the safety, tolerability, and immunogenicity of m102.4.
- It was a double-blind study, meaning neither participants nor researchers knew who received the antibody or the placebo.
- There were no deaths or severe adverse effects that would have necessitated discontinuing the study.
- The results affirmed that both single and repeated doses of m102.4 were well-tolerated and safe, with no adverse responses from participants’ immune systems.
- The monoclonal antibody m102.4 used in Dr. Playford’s clinical trial was manufactured by the Australian Institute for Bioengineering and Nanotechnology.
Regulatory Status and Future Prospects
- Dr. Bahl from ICMR noted that there were no immediate avenues for further research after the initial phase of the trial.
- Notably, m102.4 has been available since 2010 in Queensland for treating Hendra virus infections and has been shared by USU and the Henry M. Jackson Foundation for the Advancement of Military Medicine.
- Both Hendra and Nipah viruses belong to the bat-borne Paramyxoviridae family, which contains single-strand RNA of negative-sense genome, akin to viruses causing diseases like measles and influenza, replicating within infected cells.
Conclusion
- India’s proactive approach in procuring monoclonal antibodies, especially m102.4, represents a promising step in combating the Nipah virus outbreak.
- These antibodies, designed to target specific antigens, hold the potential to mitigate the impact of this recurring and dangerous virus.
Syllabus: GS 3- Economy
Prelims: Current Account Deficit
India’s Current Account Deficit (CAD) Widens in Q1 FY24
- India’s CAD increased to $9.2 billion (1.1% of GDP) in the April-June quarter, up from $1.3 billion (0.2% of GDP) in the previous quarter.
Factors Contributing to CAD Widening
- Higher Trade Deficit: The CAD widened primarily due to a higher trade deficit.
- Decline in Net Services Receipts: Net services receipts fell, mainly because of reduced exports of computer, travel, and business services, although they remained higher on a year-on-year basis.
- Decrease in Private Transfer Receipts: Private transfer receipts, including remittances from Indians working abroad, decreased to $27.1 billion from $28.6 billion in the previous quarter.
Economic Concerns
- There are concerns over the fall in remittances, which, along with slowing global growth, could impact CAD.
- Rising oil prices are expected to put additional pressure on CAD.
Income Account and Investment Highlights
- The net outgo on the income account, reflecting investment income payments, decreased to $10.6 billion from $12.6 billion in the previous quarter.
- Net foreign direct investment declined to $5.1 billion from $13.4 billion a year earlier.
- In the corresponding quarter of the previous year, there were outflows of $14.6 billion, whereas this year, there were inflows of $15.7 billion in net foreign portfolio investments.
- Net external commercial borrowings showed an inflow of $5.6 billion compared to an outflow of $2.9 billion in the previous year.
Foreign Exchange Reserves and Future Projections
- India’s foreign exchange reserves increased by $24.4 billion in the first quarter of the current fiscal year.
- ICRA Ltd. predicts that the CAD will widen further in Q2 FY24, estimating it to be between $19-21 billion (2.3% of GDP). They also project the CAD to reach $73-75 billion (2.1% of GDP) in FY24, considering an average crude oil price of $90 per barrel in H2.
G. Tidbits
Introduction
- Toto is a language spoken by a mere 1,600 people in West Bengal, near the Bhutan border.
- A professor at the University of Calcutta has undertaken an initiative to create a Toto language dictionary.
Toto Language Background
- Toto is a Sino-Tibetan language used by the tribal Toto people.
- It is typically written in the Bengali script.
- Despite the recent development of a Toto script in 2015 by community member Dhaniram Toto, most individuals still use the Bengali script or write in Bengali.
The Significance of the Dictionary
- The dictionary aims to preserve the Toto language, which has primarily been passed down orally, by documenting its vocabulary in print.
- Toto words will be translated into Bengali and English, utilising the Bengali script since the Toto script is in its early stages, and tribe members are more familiar with Bengali script.
- This dictionary is significant because the Toto community lacks any prior word collections or published primers in their language.
- Dhanua Totor Kathamala, a book by Mr. Toto, was written in Bengali, emphasising the need for this preservation effort.
Calcutta Comparatists 1919
- Mrinmoy Pramanick, an assistant professor of Comparative Indian language and Literature at the University of Calcutta, established Calcutta Comparatists 1919, a trust, to prevent marginal languages from becoming extinct.
- The trust organises collaborative workshops and incorporates literature from marginal languages into university curricula to ensure their survival and academic recognition.
The Toto Shabda Sangraha Dictionary
- Bhakta Toto, a bank employee and poet, compiled the dictionary.
- The dictionary was jointly published by Calcutta Comparatists 1919 and Bhasha Samsad, a publishing house run by Bitasta Ghoshal.
Impact of the Dictionary
- The dictionary will safeguard the Toto language from disappearing, allowing even those who study in English and Bengali to stay connected with Toto culture.
- The trust plans to publish another Bengali novel, Uttal Torsa, written by Dhaniram Toto in the near future.
H. UPSC Prelims Practice Questions
Q1. Consider the following statements, regarding monoclonal antibodies:
- Monoclonal antibodies mimic the immune system’s behaviour.
- They attach to antigens to aid in their elimination.
- Niels K. Jerne, Georges J.F. Köhler, and César Milstein received the Nobel Prize in Medicine for their work on monoclonal antibodies in 1984.
How many of the statements given above are incorrect?
- Only one
- Only two
- All three
- None
CHECK ANSWERS:-
Answer: d
Explanation: Monoclonal antibodies mimic the immune system and help eliminate antigens. The Nobel Prize was awarded in 1984 for their development.
Q2. With reference to the current account deficit, which of the following statements is/are incorrect?
- The current account deficit occurs when exports exceed imports.
- The current account includes net income and transfers.
Select the correct answer using the code given below:
- 1 only
- 2 only
- Both 1 and 2
- Neither 1 nor 2
CHECK ANSWERS:-
Answer: a
Explanation: The current account deficit occurs when imports exceed exports.
Q3. The 'Toto language' recently in the news, is related to the:
- Sino-Tibetan language written in the Bengali script.
- Dravidian language written in the Roman script.
- Austroasiatic language written in the Devanagari script.
- Indo-European language written in the Arabic script.
CHECK ANSWERS:-
Answer: a
Explanation: Toto is a Sino-Tibetan language spoken by the tribal Toto people and is written in the Bengali script.
Q4. With reference to the 13th Indo-Pacific Armies Chiefs Conference (IPACC), which of the following statements is/are correct?
- It is co-hosted by the Indian Army and the US Army Pacific at the Manekshaw Centre in New Delhi.
- The conference aims to address pressing regional concerns, strategic collaboration, and security cooperation.
Select the correct answer using the code given below:
- 1 only
- 2 only
- Both 1 and 2
- Neither 1 nor 2
CHECK ANSWERS:-
Answer: c
Explanation: Both statements are correct.
Q5. Consider the following statements, regarding Safdarjung Tomb:
- It was constructed in 1754 during the reign of Muhammad Shah.
- The monument was built on an elevated ground using red and brownish-yellow sandstone.
- The tomb is surrounded by a Charbagh-style garden.
How many of the statements given above are correct?
- Only one
- Only two
- All three
- None
CHECK ANSWERS:-
Answer: b
Explanation: Statement 1 is incorrect. Safdarjung Tomb was built in 1754, during the reign of Mughal Emperor Ahmad Shah Bahadur.
I. UPSC Mains Practice Questions
- Examine the contribution of M S Swaminathan in helping India achieve food security. (250 words, 15 marks) [GS-3; Economy]
- Illustrate the challenges arising out of India’s ageing population by the middle of this century. (250 words, 15 marks) [GS-2; Governance]
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