Difference between Hydrophobic and Hydrophilic Amino Acids

Amino acids constitute the building blocks of proteins. The 20 different types of amino acids, on the basis of physicochemical attributes, can be classified into three main classes – hydrophilic, hydrophobic and charged.

Hydrophilic amino acids are polar while hydrophobic amino acids are non-polar, this is the main difference between them.

Hydrophobic Amino Acids

  • These are the kinds of amino acids having the nature of non-polarity; they fail to interact with water and cannot be dissolved in water
  • These include Valine, Alanine, Proline, Phenylalanine and more
  • Residues typically can be seen in the protein core, which are separated from the solvent
  • It takes part in the van der Waals interactions required to stabilize the structure of proteins

Hydrophilic Amino Acids

  • These are the kinds of amino acids having the nature of polarity. It attracts water and is able to dissolve in it, given its nature
  • These include Tyrosine, Glutamine, Threonine, Serine, Asparagine

Key Difference between Hydrophobic and Hydrophilic Amino Acids

The table below depicts the difference between Hydrophobic and Hydrophilic Amino Acids.

Hydrophobic Amino Acids

Hydrophilic Amino Acids

What is it?

These are the amino acids with a nonpolar nature

These are the amino acids with a polar nature

Where does the protein occur?

At the centre

Towards the surface

How does it interact with water?

It repels when it interacts with water

It attracts when it interacts with water

Side chain

Long side chains mostly having hydrogen and carbon atoms

Has short side chains or side chains with hydrophilic groups

How is the dipole moment?

Small

Large

Examples

Valine, Alanine, Proline, Phenylalanine

Tyrosine, Glutamine, Threonine, Serine, Asparagine

You read some differences between Hydrophobic and Hydrophilic Amino Acids. For more such articles, visit us at BYJU’S NEET.

More here:

Leave a Comment

Your Mobile number and Email id will not be published. Required fields are marked *

*

*