The differentiating factor between TATA and CAAT box lies in its consensus sequence. While the TATA box is a conserved nucleotide area possessing a consensus sequence of TATAWAW, the CAAT box is a conserved nucleotide area having a consensus sequence of GGCCAATCT.
TATA Box (Goldberg–Hogness box)
- TATA box in molecular biology are DNA sequences seen in the core promoter areas of the genes in the eukaryotes and archaea.
- Pribnow box is the bacterial homolog of the TATA box that has a shorter consensus sequence.
- It is deemed to be a non-coding sequence of DNA.
- It was called so as it contains a consensus sequence distinguished by recurring T and A base pairs.
- The TATA-binding proteins function as a part of the TFIID, the huge transcription factor which initiates the transcription process.
- Once it associates with the promoter, it assigns the extra transcription factors and a string of them to associate. This leads to the construction of a huge protein complex, which determines whether to start the transcription or not.
CAAT Box
- CAAT box in molecular biology refers to a separate pattern of nucleotides with GGCCAATCT consensus sequence occurring upstream by the 60-100 bases to the initial transcription region.
- It alerts the binding site for the RNA transcription factor and is usually tagged by a conserved consensus sequence.
- The CAAT box with the GC box is known to bind normal transcription factors, both of which belong to the regulatory promoter.
- A complete expression of the gene takes place when the transcription activator proteins associate with each module in the regulatory promoter.
- In order for the CCAAT box to get activated, the protein-specific association is essential. These proteins are called CCAAT box-binding proteins.
Key Difference between TATA and CAAT Box
The table below depicts the difference between TATA and CAAT Box.
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These are conserved nucleotide areas seen at close to 25-30 base pairs upstream to the site of transcription initiation. |
These are conserved nucleotide areas seen at close to 75-80 base pairs upstream to the site of transcription initiation. |
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Consensus sequence – TATAWAW |
Consensus sequence – GGCCAATCT |
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Seen in the core promoter area of the transcription initiation sites. |
Seen at 75-80 bases upstream of the transcription initiation site. |
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A and T base pairs |
A, C and T base pairs |
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Renders binding site for transcription factors and TBP and is involved in the transcription regulation. |
Send signals to the binding site for RNA transcription factor. |
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